Vincristine sulfate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Vincristine (sulfate) 是一种微管聚合抑制剂，通过与微管蛋白结合，IC50 为 32 μM。

Vincristine (sulfate) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50?of 32 μM.(In Vitro):Vincristine inhibits net addition of tubulin dimers at assembly ends of steady-state microtubules with Ki of 85 nM. Vincristine stabilizes the spindle apparatus resulting in failure of the chromosomes to segregate leading to metaphase arrest and inhibition of mitosis at low concentrations. At higher concentrations, Vincristine may disrupt and induce total depolymerization of microtubules. Vincristine induces apoptosis in tumor cells and inhibits SH-SY5Y cell proliferation with IC50 of 0.1 μM. Vincristine induces mitotic arrest and promots the expression of caspase-3 and -9 and cyclin B, while decreasing the expression of cyclin D. Vincristine induced neurotoxicity is caused by interference with microtubule function, which results in blockage of axonal transport and thus in axonal degeneration.(In Vivo):Vincristine (3 mg/kg, i.p.) induces mean growth delay of > 120 and > 52 day, and repopulates fractions of 0.06% and 5%, administrated in mice bearing bilateral subcutaneous xenografts Rh12 or Rh18, respectively.

Vincristine inhibits net addition of tubulin dimers at assembly ends of steady-state microtubules with Ki?of 85 nM.?Vincristine stabilizes the spindle apparatus resulting in failure of the chromosomes to segregate leading to metaphase arrest and inhibition of mitosis at low concentrations. At higher concentrations, Vincristine may disrupt and induce total depolymerization of microtubules.?Vincristine induces apoptosis in tumor cells and inhibits SH-SY5Y cell proliferation with IC50 of 0.1 μM. Vincristine induces mitotic arrest and promots the expression of caspase-3 and -9 and cyclin B, while decreasing the expression of cyclin D.?Vincristine induced neurotoxicity is caused by interference with microtubule function, which results in blockage of axonal transport and thus in axonal degeneration.

Vincristine (3 mg/kg, i.p.) induces mean growth delay of > 120 and > 52 day, and repopulates fractions of 0.06% and 5%, administrated in mice bearing bilateral subcutaneous xenografts Rh12 or Rh18, respectively.

Kyocristine | Lilly 37231 | Leurocristine | Novopharm | NSC 67574 | Oncovin | VCR

Cytoskeleton/Cell Adhesion Molecules

Microtubule/Tubulin

microtubule

Cancer

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2068-78-2

923.04

C46H58N4O14S

>98% (HPLC)

Water: 60 mg/mL (65.0 mM); DMSO: 100 mg/mL (108.33 mM)

CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

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(-20℃)

With Ice Pack

≥ 2 years